Human bodies are a mammal/fungi/bacteria/insect/viral ecology which we rarely acknowledge: a normal human body is said to be composed of over 1 million, billion cells, of which only about 10% are animal. This creative PhD project explores what it means to be human when we recognise our bodies as a multi-species ecology. I take up Deleuze’s and Guattari’s call to engage in “a creative shift from the anthropocentric spatio-temporal world,” focusing on the intimate and fraught contact zones of biology, aesthetics, culture and care between Homo sapiens and Candida albicans, the single celled opportunistic fungal pathogen commonly known as thrush. Understanding and reinterpreting physical and sensual interactions is essential to explore embodied interspecies encounters and the material effects of human/non-human boundary formation. This project positions humans and thrush as co-evolved companion species involved in a biopolitical entanglement that is gendered, sexual and often ruthless.